Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11249987 | 0.99 | HRH1 (0.55) | HRH1HTR2AOPRL1OPRM1OPRK1 | |
| Bromide SCHEMBL11255909 | 0.87 | OPRL1 (0.48) | HRH1HTR2AOPRL1OPRM1OPRK1 | |
| SCHEMBL11315886 | 0.86 | HTR2A (0.54) | HRH1HTR2AOPRM1OPRK1SIGMAR1 | |
| Bromide SCHEMBL11482097 | 0.85 | HTR2A (0.53) | HRH1HTR2AOPRM1OPRK1SIGMAR1 | |
| SCHEMBL11490180 | 0.83 | HTR2A (0.54) | HRH1HTR2AOPRM1OPRK1SIGMAR1 | |
| Bromide SCHEMBL11245480 | 0.83 | HTR2A (0.52) | HRH1HTR2AOPRM1OPRK1SIGMAR1 | |
| Bromide SCHEMBL11318175 | 0.83 | HTR2A (0.54) | HRH1HTR2AOPRM1OPRK1SIGMAR1 | |
| SCHEMBL11479513 | 0.82 | HTR2A (0.53) | HRH1HTR2AOPRM1SIGMAR1DRD2 | |
| Bromide SCHEMBL11475283 | 0.82 | HRH1 (0.51) | HRH1HTR2AOPRM1OPRK1SIGMAR1 | |
| SCHEMBL11248897 | 0.82 | HRH1 (0.56) | HRH1HTR2AOPRM1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | claimed |
| US-4198418-A | ANALGESICS, TRANQUILIZERS, ANTICONVULSANTS | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | claimed |