Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD4 | P21917 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.49 |
| ▸ | HRH2 | P25021 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.49 |
| ▸ | DRD1 | P21728 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11473841 | 0.99 | HRH1 (0.56) | HRH1HTR2ADRD2DRD4CYP1A2 | |
| SCHEMBL11315886 | 0.87 | HTR2A (0.54) | HRH1HTR2ADRD2DRD4CYP1A2 | |
| Bromide SCHEMBL11245480 | 0.87 | HTR2A (0.52) | HRH1HTR2ADRD2DRD4CYP1A2 | |
| Bromide SCHEMBL11482097 | 0.86 | HTR2A (0.53) | HRH1HTR2ADRD2DRD4CYP1A2 | |
| SCHEMBL11258495 | 0.86 | SETD7 (0.47) | HRH1HTR2ADRD2DRD4HRH4 | |
| SCHEMBL11244787 | 0.86 | HTR2A (0.43) | HRH1HTR2ADRD2DRD4CYP1A2 | |
| SCHEMBL11277843 | 0.85 | HRH1 (0.54) | HRH1HTR2ADRD2DRD4CYP1A2 | |
| SCHEMBL7674579 | 0.85 | DRD2 (0.47) | HRH1HTR2ADRD2DRD4CYP1A2 | |
| Bromide SCHEMBL11253158 | 0.85 | SETD7 (0.46) | HRH1HTR2ADRD2DRD4HRH4 | |
| Bromide SCHEMBL11309721 | 0.85 | HTR2A (0.42) | HRH1HTR2ADRD2DRD4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | claimed |
| US-4198418-A | ANALGESICS, TRANQUILIZERS, ANTICONVULSANTS | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | claimed |
| EP-0016261-A1 | Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-01 | — | — | EP | disclosed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |
| US-4198418-A | ANALGESICS, TRANQUILIZERS, ANTICONVULSANTS | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |