SCHEMBL11244523

SCHEMBL11244523

O=C1c2cc(F)ccc2Oc2ccccc2C12CCNCC2

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.47
HTR2C P28335 2/20 0.40
HRH1 P35367 2/20 0.40
HTR2A P28223 1/20 0.40
NR3C2 P08235 4/20 0.39
FABP6 P51161 1/20 0.37
BACE1 P56817 1/20 0.35
CYP19A1 P11511 1/20 0.34
PARP1 P09874 1/20 0.34
PARP10 Q53GL7 1/20 0.34
AKR1B10 O60218 1/20 0.34
AKR1A1 P14550 1/20 0.34
AKR1B1 P15121 1/20 0.34
OPRM1 P35372 1/20 0.33
DRD2 P14416 1/20 0.33
SIGMAR1 Q99720 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11242648 0.99 MAPT (0.47) MAPTHTR2CHRH1HTR2ANR3C2
SCHEMBL11247226 0.85 BACE1 (0.41) HTR2CHRH1HTR2ABACE1OPRM1
SCHEMBL11238888 0.85 HRH1 (0.53) MAPTHTR2CHRH1HTR2ABACE1
Bromide SCHEMBL11474108 0.84 BACE1 (0.40) HTR2CHRH1HTR2ABACE1OPRM1
Bromide SCHEMBL11474411 0.84 HRH1 (0.52) MAPTHTR2CHRH1HTR2ABACE1
SCHEMBL11244787 0.83 HTR2A (0.43) MAPTHTR2CHRH1HTR2ANR3C2
Bromide SCHEMBL11309721 0.82 HTR2A (0.42) MAPTHTR2CHRH1HTR2ANR3C2
SCHEMBL11245513 0.80 HRH1 (0.41) MAPTHRH1HTR2A
SCHEMBL11475319 0.79 HRH1 (0.44) HRH1HTR2A
SCHEMBL7678322 0.76 HTR2C (0.51) MAPTHTR2CNR3C2FABP6AKR1B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0016261-B1 SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME HOECHST AKTIENGESELLSCHAFT (DE) 1982-12-29 EP claimed
EP-0016261-A1 Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same HOECHST AKTIENGESELLSCHAFT (DE) 1980-10-01 EP claimed
US-4198418-A ANALGESICS, TRANQUILIZERS, ANTICONVULSANTS AMERICAN HOECHST CORPORATION (US) 1980-04-15 US claimed