Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | OTUD7B | Q6GQQ9 | 14/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11277843 | 0.87 | HRH1 (0.54) | HRH1HTR2AOTUD7BMAPT | |
| SCHEMBL11244787 | 0.85 | HTR2A (0.43) | HRH1HTR2AMAPT | |
| Bromide SCHEMBL11309721 | 0.84 | HTR2A (0.42) | HRH1HTR2AMAPT | |
| SCHEMBL11475319 | 0.81 | HRH1 (0.44) | HRH1HTR2A | |
| SCHEMBL11244523 | 0.80 | MAPT (0.47) | HRH1HTR2AMAPT | |
| Hydrochloric Acid SCHEMBL11242648 | 0.79 | MAPT (0.47) | HRH1HTR2AMAPT | |
| SCHEMBL11245424 | 0.78 | HTR2A (0.54) | HRH1HTR2AOTUD7BMAPT | |
| SCHEMBL11302698 | 0.76 | DRD2 (0.47) | HRH1HTR2A | |
| SCHEMBL11254297 | 0.74 | DRD2 (0.49) | HRH1HTR2A | |
| SCHEMBL11248897 | 0.71 | HRH1 (0.56) | HRH1HTR2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | disclosed |
| EP-0016261-A1 | Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-01 | — | — | EP | disclosed |
| US-4198418-A | ANALGESICS, TRANQUILIZERS, ANTICONVULSANTS | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |