SCHEMBL11244582

SCHEMBL11244582

CCOC(=O)c1ccc2c3ccc([N+](=O)[O-])cc3[s+]([O-])c2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.49
NPC1 O15118 3/20 0.49
KCNJ1 P48048 1/20 0.47
KCNH2 Q12809 1/20 0.47
KMT2A Q03164 4/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
ALDH1A1 P00352 4/20 0.47
MEN1 O00255 3/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47
KDM4E B2RXH2 3/20 0.46
RAB9A P51151 3/20 0.46
PKM P14618 1/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
LMNA P02545 2/20 0.46
POLB P06746 1/20 0.46
ELANE P08246 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11233630 0.82 SMN1; SMN2 (0.52) MAPTNPC1KMT2ASMN1; SMN2ALDH1A1
4-Nitrobenzoic Acid Ethyl Ester SCHEMBL1500579 0.78 KCNJ1 (0.68) MAPTNPC1KCNJ1KCNH2KMT2A
SCHEMBL204674 0.78 TSHR (0.46) MAPTKMT2ASMN1; SMN2ALDH1A1MEN1
4-Nitrobenzoic Acid Ethyl Ester SCHEMBL28242787 0.76 KCNJ1 (0.67) MAPTNPC1KCNJ1KCNH2KMT2A
4-Nitrobenzoic Acid Ethyl Ester SCHEMBL27941051 0.76 KCNJ1 (0.67) MAPTNPC1KCNJ1KCNH2KMT2A
4-Nitrobenzoic Acid Ethyl Ester SCHEMBL21246856 0.76 KCNJ1 (0.67) MAPTNPC1KCNJ1KCNH2KMT2A
SCHEMBL3388760 0.76 NPC1 (0.62) MAPTNPC1KMT2ASMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL29506783 0.74 NPC1 (0.61) MAPTNPC1KMT2ASMN1; SMN2ALDH1A1
Ammonia Solution, Strong SCHEMBL9555537 0.74 NPC1 (0.61) MAPTNPC1KMT2ASMN1; SMN2ALDH1A1
Fluoride SCHEMBL27588568 0.74 NPC1 (0.61) MAPTNPC1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4334078-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS HOFFMANN-LA ROCHE INC. (US) 1982-06-08 US disclosed
US-4219657-A USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1980-08-26 US disclosed