Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MAT2A | P31153 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244582 | 0.82 | MAPT (0.49) | SMN1; SMN2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL28383910 | 0.79 | KDM4E (0.68) | SMN1; SMN2KDM4EHCRTR1MEN1KMT2A | |
| SCHEMBL3164470 | 0.78 | PARP1 (0.49) | SMN1; SMN2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL29951173 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL10484294 | 0.72 | ALDH1A1 (0.59) | SMN1; SMN2KDM4EHCRTR1MEN1KMT2A | |
| SCHEMBL10484070 | 0.72 | KMT2A (0.59) | SMN1; SMN2KDM4EHCRTR1MEN1KMT2A | |
| SCHEMBL11244864 | 0.71 | GABRP (0.60) | SMN1; SMN2KDM4EHCRTR1MEN1KMT2A | |
| SCHEMBL6009670 | 0.71 | KDM4E (0.84) | SMN1; SMN2KDM4EHCRTR1MEN1KMT2A | |
| SCHEMBL28260157 | 0.70 | ALDH1A1 (0.57) | SMN1; SMN2KDM4EHCRTR1MEN1KMT2A | |
| SCHEMBL110276 | 0.69 | CYP4F2 (0.65) | SMN1; SMN2KDM4EKMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |