Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 16/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 13/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 12/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10478199 | 0.90 | ADRB3 (0.78) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL11255869 | 0.88 | ADRB3 (0.77) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL11253857 | 0.87 | ADRB3 (0.77) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL11251142 | 0.87 | ADRB3 (0.77) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL11247530 | 0.87 | ADRB3 (0.77) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL10860224 | 0.87 | ADRB3 (0.52) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL11255890 | 0.86 | ADRB3 (0.77) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| Hydrochloric Acid SCHEMBL10859952 | 0.86 | ADRB3 (0.52) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL11148041 | 0.85 | ADRB3 (0.64) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| SCHEMBL9812002 | 0.82 | ADRB3 (0.55) | ADRB3ADRB1ADRB2CYP2D6ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | claimed |
| EP-0023385-B1 | ETHANAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | disclosed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |