Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 9/20 | 0.40 |
| ▸ | CES1 | P23141 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10447727 | 0.93 | FAAH (0.41) | TSHRCES2FAAHCES1PLA2G4A | |
| SCHEMBL24938544 | 0.86 | FAAH (0.53) | FAAHCES1TRPV1PLA2G4A | |
| SCHEMBL28417663 | 0.86 | FAAH (0.53) | FAAHCES1TRPV1PLA2G4A | |
| SCHEMBL11244957 | 0.86 | PTPN7 (0.36) | TSHRCES2LPAR1LPAR3FAAH | |
| SCHEMBL11245966 | 0.85 | CES2 (0.50) | TSHRCES2LPAR1LPAR3FAAH | |
| SCHEMBL24234728 | 0.85 | CES2 (0.50) | TSHRCES2LPAR1LPAR3FAAH | |
| SCHEMBL6934289 | 0.85 | CES2 (0.50) | TSHRCES2LPAR1LPAR3FAAH | |
| SCHEMBL83980 | 0.85 | CES2 (0.50) | TSHRCES2LPAR1LPAR3FAAH | |
| SCHEMBL465782 | 0.85 | CES2 (0.50) | TSHRCES2LPAR1LPAR3FAAH | |
| SCHEMBL23034519 | 0.85 | CES2 (0.50) | TSHRCES2LPAR1LPAR3FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | claimed |
| US-4318914-A | Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4310545-A | Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino) phenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1982-01-12 | — | — | US | disclosed |
| US-4305959-A | Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1981-12-15 | — | — | US | disclosed |
| US-4205085-A | Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino)phenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1980-05-27 | — | — | US | disclosed |