Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.55 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808170 | 0.79 | MAPT (0.53) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3604799 | 0.78 | ALOX5 (0.61) | MAPTADORA3KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3594785 | 0.78 | MAPT (0.65) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL10750014 | 0.78 | MAPT (0.55) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30660071 | 0.77 | MAPT (0.48) | MAPTADORA3KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3602636 | 0.77 | ABL1 (0.65) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3610442 | 0.77 | ALOX5 (0.59) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3603727 | 0.77 | GSTO1 (0.60) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3598628 | 0.77 | MAPT (0.58) | MAPTADORA3KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3610890 | 0.77 | MAPT (0.64) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4315009-A | Antisecretory guanidine derivatives and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-02-09 | — | — | US | disclosed |
| EP-0003640-B1 | ANTISECRETORY GUANIDINE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-01-27 | — | — | EP | disclosed |
| EP-0003640-A2 | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-08-22 | — | — | EP | disclosed |