Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
| ▸ | CA2 | P00918 | 1/20 | 0.66 |
| ▸ | CA4 | P22748 | 1/20 | 0.66 |
| ▸ | CA6 | P23280 | 1/20 | 0.66 |
| ▸ | CA7 | P43166 | 1/20 | 0.66 |
| ▸ | TPMT | P51580 | 1/20 | 0.66 |
| ▸ | CA9 | Q16790 | 1/20 | 0.66 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.56 |
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stearic Acid SCHEMBL11245833 | 0.92 | CA12 (0.56) | CA12CA1CA2CA4CA6 | |
| Dodecanoate SCHEMBL109696 | 0.89 | HTT (0.68) | POLB | |
| SCHEMBL109694 | 0.86 | TOP2A (0.61) | CA12CA1CA2CA4CA6 | |
| SCHEMBL14672687 | 0.86 | TOP2A (0.61) | CA12CA1CA2CA4CA6 | |
| SCHEMBL18682279 | 0.85 | PLA2G4B (0.74) | CA12CA1CA2CA4CA6 | |
| SCHEMBL16077692 | 0.85 | PLA2G4B (0.74) | CA12CA1CA2CA4CA6 | |
| SCHEMBL9305512 | 0.85 | SMPD1 (0.75) | CA12CA1CA2CA4CA6 | |
| SCHEMBL29171434 | 0.85 | PLA2G4B (0.74) | CA12CA1CA2CA4CA6 | |
| SCHEMBL29171422 | 0.85 | PLA2G4B (0.74) | CA12CA1CA2CA4CA6 | |
| SCHEMBL2312195 | 0.85 | PLA2G4B (0.74) | CA12CA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4342875-A | STABILIZERS FOR OLEFIN POLYMERS | CINCINNATI-MILACRON, INC. (US) | 1982-08-03 | — | — | US | disclosed |