Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | TPMT | P51580 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14672687 | 1.00 | TOP2A (0.61) | TOP2ATSHRPLA2G4BCA12CA1 | |
| SCHEMBL8371960 | 0.88 | TOP2A (0.60) | TOP2AMGLLALOX15THRATHRB | |
| SCHEMBL118994 | 0.88 | TOP2A (0.60) | TOP2AMGLLALOX15THRATHRB | |
| SCHEMBL8373083 | 0.88 | TOP2A (0.60) | TOP2AMGLLALOX15THRATHRB | |
| SCHEMBL8372910 | 0.88 | TOP2A (0.60) | TOP2AMGLLALOX15THRATHRB | |
| SCHEMBL5088072 | 0.88 | TOP2A (0.60) | TOP2AMGLLALOX15THRATHRB | |
| SCHEMBL9516469 | 0.87 | TSHR (0.58) | TOP2ATSHRPLA2G4BCA12CA1 | |
| Stearic Acid SCHEMBL11246448 | 0.86 | CA12 (0.66) | TSHRPLA2G4BCA12CA1CA2 | |
| SCHEMBL1740685 | 0.86 | ALOX15 (0.53) | TOP2ATSHRALOX15ALDH1A1HPGD | |
| SCHEMBL1740674 | 0.86 | ALOX15 (0.53) | TOP2ATSHRALOX15ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424872-A1 | NEUROPROTECTIVE COMPOUNDS AND THEIR USE | The MCW Research Foundation, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126719-A1 | NEUROPROTECTIVE COMPOUNDS AND THEIR USE | MCW RESEARCH FOUNDATION, INC. (US) | 2010-11-04 | — | — | WO | disclosed |