Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237788 | 0.83 | AAK1 (0.49) | PIK3CBDYRK1AAAK1TLR8TLR7 | |
| SCHEMBL7282401 | 0.79 | PIK3CD (0.50) | PIK3CBALDH1A1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL7272389 | 0.76 | ALDH1A1 (0.60) | PIK3CBDYRK1AAAK1ALDH1A1CYP3A4 | |
| SCHEMBL14934011 | 0.76 | AAK1 (0.49) | PIK3CBDYRK1AAAK1TLR8TLR7 | |
| SCHEMBL30308690 | 0.75 | DYRK1A (0.65) | PIK3CBDYRK1ACYP3A4CYP2D6PSEN1 | |
| SCHEMBL1896511 | 0.75 | DYRK1A (0.65) | PIK3CBDYRK1ACYP3A4CYP2D6PSEN1 | |
| SCHEMBL11377602 | 0.75 | PIK3CB (0.58) | PIK3CBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11153504 | 0.74 | PIK3CB (0.72) | PIK3CBAAK1PSEN1PSEN2APH1B | |
| SCHEMBL11170792 | 0.74 | TLR8 (0.60) | PIK3CBDYRK1AAAK1TLR8TLR7 | |
| Iodide SCHEMBL9618570 | 0.73 | DYRK1A (0.63) | PIK3CBDYRK1ACYP3A4CYP2D6PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |