Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 6/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244055 | 0.83 | ARG1 (0.51) | GRIK1ARG1CYP1A2ALOX15CYP2C19 | |
| SCHEMBL1812137 | 0.83 | ARG1 (0.51) | GRIK1ARG1CYP1A2ALOX15CYP2C19 | |
| Hydrochloric Acid SCHEMBL5234960 | 0.78 | HIF1A (0.43) | EPHX2ATMMETAP2METAP1 | |
| Bromide SCHEMBL1582234 | 0.75 | HIF1A (0.43) | EPHX2ALDH1A1ATMMETAP2METAP1 | |
| SCHEMBL4862322 | 0.75 | ARG1 (0.56) | GRIK1ARG1CYP1A2ALOX15CYP2C19 | |
| Iodide SCHEMBL1969660 | 0.73 | HIF1A (0.44) | CYP1A2CYP2C19CYP2D6EPHX2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11250863 | 0.71 | F2 (0.41) | GRIK1ARG1HRH3 | |
| Bromide SCHEMBL6428595 | 0.70 | HIF1A (0.44) | CYP1A2CYP2C19CYP2D6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11237072 | 0.70 | GRIK1 (0.42) | GRIK1ARG1HRH3 | |
| SCHEMBL5517139 | 0.70 | GRIN2D (0.57) | ARG1CYP1A2ALOX15CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |