Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 11/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10965559 | 0.81 | CYP11B1 (0.57) | CYP17A1CYP11B1CYP11B2CYP19A1POLB | |
| SCHEMBL5297627 | 0.75 | CYP17A1 (0.82) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL11429930 | 0.74 | CYP19A1 (0.43) | CYP17A1CYP11B1CYP11B2CYP19A1KMT2A | |
| SCHEMBL5289562 | 0.74 | CYP17A1 (0.56) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL11465747 | 0.73 | CYP19A1 (0.78) | CYP17A1CYP11B1CYP11B2CYP19A1KMT2A | |
| SCHEMBL5285395 | 0.73 | CYP17A1 (0.52) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL5293350 | 0.73 | CYP17A1 (0.52) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL5292341 | 0.73 | CYP17A1 (0.52) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL5289895 | 0.73 | CYP17A1 (0.52) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL5298752 | 0.73 | CYP17A1 (0.52) | CYP17A1CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015750-B1 | 1-(NAPHTHYL-N-PROPYL)IMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, METHODS OF MAKING THEM AND THEIR USE FOR PHARMACEUTICALS | SYNTEX (U.S.A.) INC. (US) | 1982-11-24 | — | — | EP | disclosed |
| EP-0015750-B1 | 1-(NAPHTHYL-N-PROPYL)IMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, METHODS OF MAKING THEM AND THEIR USE FOR PHARMACEUTICALS | SYNTEX (U.S.A.) INC. (US) | 1982-11-24 | — | — | EP | disclosed |
| US-4293561-A | ANTICONVULSANT ANTISECRETORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-10-06 | — | — | US | disclosed |
| US-4293561-A | ANTICONVULSANT ANTISECRETORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-10-06 | — | — | US | disclosed |
| EP-0015750-A1 | 1-(Naphthyl-n-propyl)imidazole derivatives, compositions containing them, methods of making them and their use for pharmaceuticals | SYNTEX (U.S.A.) INC. (US) | 1980-09-17 | — | — | EP | disclosed |
| EP-0015750-A1 | 1-(Naphthyl-n-propyl)imidazole derivatives, compositions containing them, methods of making them and their use for pharmaceuticals | SYNTEX (U.S.A.) INC. (US) | 1980-09-17 | — | — | EP | disclosed |
| EP-0015750-A1 | 1-(Naphthyl-n-propyl)imidazole derivatives, compositions containing them, methods of making them and their use for pharmaceuticals | SYNTEX (U.S.A.) INC. (US) | 1980-09-17 | — | — | EP | disclosed |