Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | PARG | Q86W56 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25720574 | 0.83 | CYP1A2 (0.48) | CYP1A2PARGKMT2A | |
| SCHEMBL12434372 | 0.83 | PARG (0.54) | CYP1A2PARGKMT2A | |
| SCHEMBL2680469 | 0.81 | CYP1A2 (0.54) | CYP1A2PARGKMT2A | |
| Hydrochloric Acid SCHEMBL11229179 | 0.75 | HPGD (0.57) | BRD4CYP1A2KMT2A | |
| Hydrochloric Acid SCHEMBL11512078 | 0.75 | SLC6A2 (0.45) | CYP1A2KMT2A | |
| SCHEMBL24087808 | 0.75 | PARG (0.80) | PARG | |
| Hydrochloric Acid SCHEMBL2264513 | 0.74 | CRHR1 (0.47) | CYP1A2PARGKMT2A | |
| Hydrochloric Acid SCHEMBL28958073 | 0.73 | DDB1 (0.48) | — | |
| SCHEMBL21605952 | 0.71 | CYP1A2 (0.49) | CYP1A2DRD2KMT2A | |
| SCHEMBL8268236 | 0.71 | CYP1A2 (0.49) | CYP1A2DRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005610-B1 | 1-(HETEROCYCLYLALKYL)-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONES, THEIR PREPARATION, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS BETA-ADRENERGIC RECEPTOR BLOCKERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-15 | — | — | EP | disclosed |
| US-4181802-A | ADRENERGIC BLOCKING AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-01-01 | — | — | US | disclosed |