Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifezolac SCHEMBL11182574 | 0.83 | KDM4E (0.51) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL11724930 | 0.82 | SMN1; SMN2 (0.54) | KMT2AKDM4EUSP2MAPTNPSR1 | |
| SCHEMBL11731343 | 0.82 | SMN1; SMN2 (0.49) | KMT2AKDM4EUSP2MAPTNPSR1 | |
| SCHEMBL14747800 | 0.81 | PTGS2 (0.50) | CYP1A2CYP2C9CYP2C19SMN1; SMN2PTGS2 | |
| SCHEMBL11249543 | 0.80 | CYP2C9 (0.47) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL8122183 | 0.80 | CYP2C9 (0.47) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL11258179 | 0.80 | CA1 (0.43) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL27574894 | 0.78 | CYP2C9 (0.58) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL11258090 | 0.78 | CYP2C9 (0.48) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL11245216 | 0.78 | KMT2A (0.48) | KMT2ACYP1A2CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4325962-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIDYRETICS | BYK-GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-04-20 | — | — | US | disclosed |
| US-4146721-A | ANALGESICS, ANTIINFLAMMATORY AGENTS AND ANTIPYRETICS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1979-03-27 | — | — | US | disclosed |