Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240531 | 0.77 | CA12 (0.39) | GAAMAPTMAPK1PDE3BPDE3A | |
| SCHEMBL11117779 | 0.76 | PDE3B (0.56) | MAPTPDE3BPDE3AKDM4EHPGD | |
| SCHEMBL11010732 | 0.75 | PDE4A (0.53) | GAAMAPTMAPK1PDE3BPDE3A | |
| SCHEMBL7338278 | 0.72 | ESR1 (0.42) | GAAPDE3BPDE3AKDM4EHPGD | |
| SCHEMBL10890724 | 0.72 | PDE3B (0.42) | PDE3BPDE3AMAP4K1CA12CA9 | |
| SCHEMBL10891718 | 0.71 | APP (0.46) | GAAMAPT | |
| SCHEMBL1150800 | 0.71 | NPC1 (0.54) | MAPTKDM4EHSD17B10ALDH1A1HTT | |
| SCHEMBL11117023 | 0.70 | GAA (0.42) | GAAMAPTMAPK1KDM4EHPGD | |
| SCHEMBL11080287 | 0.70 | KMT2A (0.51) | PDE3BPDE3AKDM4EHPGDHSD17B10 | |
| SCHEMBL7331775 | 0.70 | MAOA (0.43) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |