Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10887627 | 0.85 | ALDH1A1 (0.42) | MAPTGAA | |
| SCHEMBL10888824 | 0.81 | MAPT (0.52) | MAPTXDHGAA | |
| SCHEMBL7338278 | 0.80 | ESR1 (0.42) | GAA | |
| SCHEMBL7331775 | 0.78 | MAOA (0.43) | MGAMGAASIMGAM2 | |
| SCHEMBL10992753 | 0.76 | PDE3B (0.62) | APPMAPTADORA3ADORA2AADORA1 | |
| SCHEMBL10890724 | 0.73 | PDE3B (0.42) | ADORA2AADORA1 | |
| SCHEMBL10995836 | 0.72 | GAA (0.41) | APPADORA3ADORA2AADORA1GUSB | |
| SCHEMBL10891285 | 0.72 | KDM4E (0.65) | APPGAA | |
| SCHEMBL11010732 | 0.72 | PDE4A (0.53) | MAPTGAA | |
| SCHEMBL7318943 | 0.71 | HPGD (0.49) | MAPTGUSBMGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599423-A | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1986-07-08 | — | — | US | claimed |
| US-4465686-A | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1984-08-14 | — | — | US | claimed |
| EP-0074091-A2 | 2(1H)-pyridinones and preparation thereof | STERLING DRUG INC. (US) | 1983-03-16 | — | — | EP | claimed |
| US-4599423-A | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1986-07-08 | — | — | US | disclosed |
| US-4465686-A | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0074091-A2 | 2(1H)-pyridinones and preparation thereof | STERLING DRUG INC. (US) | 1983-03-16 | — | — | EP | disclosed |