SCHEMBL11277843

SCHEMBL11277843

N#CN1CCC2(CC1)C(=O)c1cc(Cl)ccc1Oc1ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 5/20 0.54
HTR2A P28223 3/20 0.54
OTUD7B Q6GQQ9 3/20 0.39
DRD2 P14416 5/20 0.38
DRD4 P21917 5/20 0.38
CYP1A2 P05177 3/20 0.38
CYP3A4 P08684 3/20 0.38
CYP2D6 P10635 3/20 0.38
TP53 P04637 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
MAPT P10636 1/20 0.38
CYP2C19 P33261 1/20 0.38
HRH4 Q9H3N8 5/20 0.37
HRH2 P25021 3/20 0.37
ADRB2 P07550 2/20 0.37
CHRM2 P08172 2/20 0.37
CHRM4 P08173 2/20 0.37
HTR1A P08908 2/20 0.37
CHRM5 P08912 2/20 0.37
ADRA2A P08913 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11245513 0.87 HRH1 (0.41) HRH1HTR2AOTUD7BMAPT
SCHEMBL11248897 0.85 HRH1 (0.56) HRH1HTR2ADRD2DRD4CYP1A2
Bromide SCHEMBL11473841 0.84 HRH1 (0.56) HRH1HTR2ADRD2DRD4CYP1A2
SCHEMBL11315886 0.82 HTR2A (0.54) HRH1HTR2ADRD2DRD4CYP1A2
SCHEMBL11490180 0.82 HTR2A (0.54) HRH1HTR2ADRD2DRD4CYP1A2
Bromide SCHEMBL11482097 0.81 HTR2A (0.53) HRH1HTR2ADRD2DRD4CYP1A2
SCHEMBL11238888 0.80 HRH1 (0.53) HRH1HTR2ADRD2DRD4CYP1A2
Bromide SCHEMBL11318175 0.80 HTR2A (0.54) HRH1HTR2ADRD2DRD4CYP1A2
Bromide SCHEMBL11245480 0.80 HTR2A (0.52) HRH1HTR2ADRD2DRD4CYP1A2
SCHEMBL11244394 0.80 HRH1 (0.56) HRH1HTR2ADRD2OPRM1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0016261-B1 SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME HOECHST AKTIENGESELLSCHAFT (DE) 1982-12-29 EP disclosed
EP-0016261-A1 Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same HOECHST AKTIENGESELLSCHAFT (DE) 1980-10-01 EP disclosed
US-4198418-A ANALGESICS, TRANQUILIZERS, ANTICONVULSANTS AMERICAN HOECHST CORPORATION (US) 1980-04-15 US disclosed