Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HBB | P68871 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PNP | P00491 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | HINT1 | P49773 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369791 | 0.90 | HDAC1 (0.48) | MEN1KMT2AHBBMAPK1TSHR | |
| SCHEMBL11729464 | 0.89 | HDAC1 (0.48) | MEN1KMT2AHBBMAPK1TSHR | |
| SCHEMBL11249908 | 0.87 | P2RY11 (0.44) | EGFRMEN1KMT2AHBBMAPK1 | |
| SCHEMBL4094131 | 0.86 | EGFR (0.64) | EGFRENPP1NT5E | |
| SCHEMBL11249941 | 0.83 | MEN1 (0.57) | CDK1CCNB1CCNE1CDK2MEN1 | |
| SCHEMBL10648298 | 0.83 | HDAC6 (0.47) | MEN1KMT2AHBBMAPK1HSD17B10 | |
| SCHEMBL8660736 | 0.82 | PNP (0.67) | MEN1KMT2AHBBMAPK1TSHR | |
| SCHEMBL11260801 | 0.81 | MEN1 (0.52) | EGFRMEN1KMT2AHBBMAPK1 | |
| SCHEMBL11242909 | 0.80 | P2RX7 (0.48) | MEN1KMT2AHBBMAPK1TSHR | |
| SCHEMBL11724984 | 0.78 | PNP (0.60) | CDK1CCNB1CCNE1CDK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360522-A | VIRICIDES | BURROUGHS WELLCOME CO. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4323573-A | VIRICIDES | BURROUGHS WELLCOME CO. (US) | 1982-04-06 | — | — | US | disclosed |
| US-4294831-A | ANTIVIRAL ACTIVITY | BURROUGHS WELLCOME CO. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4199574-A | Methods and compositions for treating viral infections and guanine acyclic nucleosides | BURROUGHS WELLCOME CO. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4146715-A | ANTIVIRAL AGENTS | BURROUGHS WELLCOME CO. (US) | 1979-03-27 | — | — | US | disclosed |