Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11252493 | 0.84 | TDP1 (0.48) | TDP1RXRARXRBCYP1A2KDM4E | |
| SCHEMBL11258381 | 0.81 | TDP1 (0.48) | TDP1CYP1A2KDM4EMAPTPTGDR2 | |
| SCHEMBL11257137 | 0.81 | TDP1 (0.48) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11261730 | 0.81 | TDP1 (0.44) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11262924 | 0.80 | HPGD (0.36) | CNR2CYP1A2KDM4EMAPTEDNRA | |
| SCHEMBL11250186 | 0.79 | PTGDR2 (0.43) | TDP1RXRARXRBCNR2CYP1A2 | |
| SCHEMBL11251835 | 0.79 | TDP1 (0.54) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL31644190 | 0.78 | TDP1 (0.56) | TDP1RXRARXRBCYP1A2MAPT | |
| SCHEMBL11257961 | 0.77 | KDM4E (0.42) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11262890 | 0.77 | CNR2 (0.38) | TDP1CNR2KDM4EMAPTSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |