Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.39 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11252493 | 0.84 | TDP1 (0.48) | TDP1PPARGNR1H2NR1H3PTGS2 | |
| SCHEMBL11258381 | 0.81 | TDP1 (0.48) | TDP1PTGS2CXCL8TTRNR1H4 | |
| SCHEMBL11257137 | 0.81 | TDP1 (0.48) | TDP1PPARGNR1H2NR1H3CXCL8 | |
| SCHEMBL11249334 | 0.81 | TDP1 (0.44) | TDP1PPARGNR1H2NR1H3PTGS2 | |
| SCHEMBL11259158 | 0.79 | TDP1 (0.42) | TDP1PPARGNR1H2NR1H3KDM4E | |
| SCHEMBL11251835 | 0.79 | TDP1 (0.54) | TDP1PPARGNR1H2NR1H3KDM4E | |
| SCHEMBL11285948 | 0.77 | NR1H2 (0.42) | TDP1PPARGNR1H2NR1H3KDM4E | |
| SCHEMBL11266224 | 0.77 | CXCL8 (0.41) | TDP1PARP14PTGS2CXCL8ACHE | |
| SCHEMBL11246786 | 0.74 | LMNA (0.48) | TDP1PPARGNR1H2NR1H3KDM4E | |
| SCHEMBL11311256 | 0.73 | TDP1 (0.53) | TDP1PPARGNR1H2NR1H3PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |