Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244605 | 0.87 | HTT (0.50) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11261746 | 0.87 | HTT (0.50) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11255985 | 0.87 | HTT (0.50) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11250658 | 0.87 | HTT (0.60) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11249625 | 0.87 | HTT (0.53) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11252801 | 0.87 | HTT (0.77) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11258517 | 0.87 | HTT (0.53) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11249084 | 0.84 | MEN1 (0.57) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11264267 | 0.84 | HTT (0.47) | HTTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL11052142 | 0.83 | MEN1 (0.53) | HTTMEN1KMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |