Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CTH | P32929 | 1/20 | 0.35 |
| ▸ | CBS | P35520 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 3/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168709 | 0.90 | — | — | |
| SCHEMBL11280732 | 0.87 | TSHR (0.39) | APEX1FNTAFNTBTSHRCTH | |
| SCHEMBL27845788 | 0.87 | TSHR (0.39) | APEX1FNTAFNTBTSHRCTH | |
| SCHEMBL28279642 | 0.87 | TSHR (0.39) | APEX1FNTAFNTBTSHRCTH | |
| Ammonia Solution, Strong SCHEMBL11317665 | 0.87 | TSHR (0.39) | APEX1FNTAFNTBTSHRCTH | |
| Methane SCHEMBL9595604 | 0.87 | TSHR (0.39) | APEX1FNTAFNTBTSHRCTH | |
| Monoethanolamine SCHEMBL5030530 | 0.77 | TSHR (0.37) | LMNAFNTAFNTBTSHRCTH | |
| Monoethanolamine SCHEMBL27678397 | 0.77 | TSHR (0.37) | LMNAFNTAFNTBTSHRCTH | |
| SCHEMBL4834624 | 0.76 | FNTA (0.55) | LMNAAPEX1FNTAFNTBTSHR | |
| Octane SCHEMBL28758977 | 0.76 | PAM (0.50) | TSHROR51E2SLC22A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |