Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | FABP2 | P12104 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29519530 | 1.00 | HTT (0.48) | HTTMAPTHDAC7LTB4R2SLC6A4 | |
| SCHEMBL28126166 | 0.86 | HTT (0.51) | HTTMAPTLTB4R2SLC6A4SLC6A3 | |
| SCHEMBL5024503 | 0.85 | LTB4R2 (0.51) | HTTMAPTLTB4R2MEN1KMT2A | |
| SCHEMBL2645320 | 0.83 | MAPK14 (0.54) | MAPTMEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL1927478 | 0.82 | BCAT2 (0.61) | HTTMAPT | |
| SCHEMBL10794588 | 0.82 | DHODH (0.54) | MAPTLTB4R2MEN1KMT2AAKR1C2 | |
| SCHEMBL11435938 | 0.81 | MAPT (0.53) | HTTMAPTHDAC7SMN1; SMN2PTGS1 | |
| SCHEMBL14397839 | 0.81 | KEAP1 (0.48) | LTB4R2CES2CES1MEN1KMT2A | |
| SCHEMBL14397837 | 0.81 | CYP2C9 (0.50) | HTTMAPTLTB4R2PTGS1PTGS2 | |
| SCHEMBL14398096 | 0.81 | CYP2C9 (0.50) | HTTMAPTLTB4R2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015776-B1 | 1,1'-BIPHENYL-2-YL ALKYLAMINE DERIVATIVES, THEIR PRODUCTION AND CARDIOVASCULAR PREPARATIONS CONTAINING SAME | ELI LILLY AND COMPANY (US) | 1982-06-30 | — | — | EP | disclosed |
| US-4277471-A | 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0015776-A1 | 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same | ELI LILLY AND COMPANY (US) | 1980-09-17 | — | — | EP | disclosed |