Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 2/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248535 | 0.99 | HMOX1 (0.66) | HMOX1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11241491 | 0.90 | HMOX1 (0.80) | HMOX1 | |
| SCHEMBL11239437 | 0.88 | HMOX1 (0.64) | HMOX1 | |
| SCHEMBL11241840 | 0.88 | HMOX1 (0.58) | HMOX1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11244850 | 0.88 | HMOX1 (0.84) | HMOX1 | |
| SCHEMBL11236454 | 0.87 | HMOX1 (0.66) | HMOX1CYP19A1CYP11B1 | |
| SCHEMBL11252474 | 0.87 | HMOX1 (0.62) | HMOX1 | |
| SCHEMBL11241841 | 0.87 | HMOX1 (0.62) | HMOX1 | |
| SCHEMBL11251950 | 0.86 | HMOX1 (0.56) | HMOX1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11248183 | 0.86 | HMOX1 (0.74) | HMOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |