Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16566170 | 0.87 | ALDH1A1 (0.50) | ALDH1A1MAPTGAAALOX12LMNA | |
| SCHEMBL3485977 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTGAALMNA | |
| SCHEMBL774049 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTGAALMNA | |
| SCHEMBL28243691 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTGAALMNA | |
| SCHEMBL14821834 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL20375597 | 0.79 | MAPT (0.42) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL13478303 | 0.79 | L3MBTL1 (0.47) | ALDH1A1MAPTGAAALOX12LMNA | |
| SCHEMBL13057567 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KMT2AMAPTGAAALOX12 | |
| SCHEMBL16450893 | 0.79 | HSP90AA1 (0.59) | USP2ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6545138 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPTGAAALOX12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309541-A | CHEMICAL INTERMEDIATES TO QUINAZOLINE HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4255429-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| EP-0009465-A1 | N-(1-(4-amino-2-quinazolinyl)-3 or 4-piperidyl lactames, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-04-02 | — | — | EP | disclosed |