Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCKDK | O14874 | 2/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30414903 | 0.87 | KDM4E (0.48) | BCKDKMCL1RXFP1TSHRSRD5A2 | |
| SCHEMBL204515 | 0.87 | KDM4E (0.48) | BCKDKMCL1RXFP1TSHRSRD5A2 | |
| SCHEMBL11247121 | 0.84 | BCKDK (0.51) | BCKDKMCL1RXFP1TTRTSHR | |
| SCHEMBL30414825 | 0.83 | KDM4E (0.46) | BCKDKMCL1RXFP1TSHRSRD5A2 | |
| SCHEMBL14020124 | 0.83 | KDM4E (0.60) | BCKDKMCL1RXFP1TTRTSHR | |
| Potassium Ion SCHEMBL11253001 | 0.81 | CA1 (0.50) | BCKDKMCL1RXFP1TTRPRSS12 | |
| SCHEMBL11244432 | 0.81 | CYP1A2 (0.53) | MCL1TTRTSHRALOX15NPC1 | |
| SCHEMBL4922527 | 0.79 | BCKDK (0.53) | BCKDKMCL1RXFP1MEN1KMT2A | |
| SCHEMBL31228783 | 0.79 | BCKDK (0.53) | BCKDKMCL1RXFP1MEN1KMT2A | |
| SCHEMBL29762008 | 0.79 | CYP1A2 (0.54) | MCL1TTRTSHRALOX15NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |