SCHEMBL11253258

SCHEMBL11253258

Clc1ccc(CC2(CCn3ccnc3)SCCCS2)cc1

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.50
CYP19A1 P11511 1/20 0.50
CYP11B1 P15538 1/20 0.50
CYP11B2 P19099 1/20 0.50
CYP2B6 P20813 1/20 0.50
TP53 P04637 2/20 0.44
KDM4E B2RXH2 1/20 0.44
TSHR P16473 1/20 0.44
QPCT Q16769 2/20 0.43
ALDH1A1 P00352 1/20 0.41
HMOX1 P09601 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11264249 0.95 CYP2A6 (0.52) CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6
SCHEMBL11265708 0.93 CYP2A6 (0.48) CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6
SCHEMBL11256551 0.89 CYP2A6 (0.49) CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6
SCHEMBL11258631 0.88 CYP11B1 (0.49) CYP19A1CYP11B1CYP11B2QPCTALDH1A1
SCHEMBL11269020 0.88 HMOX1 (0.50) CYP19A1CYP11B1CYP11B2HMOX1
SCHEMBL11262189 0.88 CYP2A6 (0.50) CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6
SCHEMBL11262573 0.88 CYP2A6 (0.52) CYP2A6CYP19A1CYP11B1CYP11B2CYP2B6
SCHEMBL11262007 0.88 CYP19A1 (0.47) CYP19A1CYP11B1CYP11B2QPCTHMOX1
SCHEMBL11254617 0.86 CYP19A1 (0.40) CYP19A1HMOX1
SCHEMBL11289197 0.85 MEN1 (0.48) CYP19A1CYP11B1TP53TSHRQPCT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4359475-A SPERMICIDES, MICROBIOCIDES OR ANTICONVULSANTS SYNTEX (U.S.A.) INC. (US) 1982-11-16 US disclosed