Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 3/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 12/20 | 0.40 |
| ▸ | BCHE | P06276 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | LIG1 | P18858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957232 | 0.79 | PRMT6 (0.59) | APEX1PRMT6ACHEBCHE | |
| SCHEMBL11254687 | 0.78 | PRMT6 (0.55) | APEX1PRMT6ACHEBCHE | |
| SCHEMBL11252579 | 0.78 | PRMT6 (0.57) | PRMT6ACHEBCHE | |
| SCHEMBL11256940 | 0.77 | GLA (0.43) | APEX1TTRMEN1KMT2AALDH1A1 | |
| SCHEMBL11252584 | 0.76 | PRMT6 (0.55) | PRMT6ACHEBCHE | |
| SCHEMBL11253268 | 0.75 | APEX1 (0.54) | APEX1PRMT6TTRMEN1KMT2A | |
| SCHEMBL11260097 | 0.74 | PRMT6 (0.52) | PRMT6ACHEBCHE | |
| SCHEMBL10959685 | 0.71 | PRMT6 (0.59) | PRMT6ACHEBCHE | |
| SCHEMBL7995056 | 0.69 | PRMT6 (1.00) | PRMT6ACHEBCHE | |
| SCHEMBL13402279 | 0.69 | APEX1 (1.00) | APEX1TTRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001699-B1 | DERIVATIVES OF FURYL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1982-02-24 | — | — | EP | disclosed |
| US-4288443-A | HISTAMINE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1981-09-08 | — | — | US | disclosed |
| EP-0001699-A2 | Derivatives of furyl compounds, their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1979-05-02 | — | — | EP | disclosed |