Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11259118 | 0.84 | KCNQ3 (0.45) | LMNAHTTSMN1; SMN2TMPRSS4KDR | |
| SCHEMBL6691674 | 0.83 | MAPT (0.41) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL11245874 | 0.83 | KDR (0.50) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL6698612 | 0.82 | IDO1 (0.44) | MAPTMEN1KMT2ALMNANPC1 | |
| SCHEMBL11263943 | 0.82 | HTT (0.46) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL11258914 | 0.81 | HTT (0.45) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL6697641 | 0.79 | MAOB (0.47) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL11250207 | 0.79 | PLAU (0.36) | MAPT | |
| SCHEMBL11255183 | 0.79 | KIF11 (0.49) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL20096581 | 0.77 | EPHX1 (0.57) | MAPTMEN1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |