Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 15/20 | 0.72 |
| ▸ | DRD4 | P21917 | 14/20 | 0.67 |
| ▸ | DRD2 | P14416 | 13/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270827 | 0.91 | DRD3 (0.88) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL11769854 | 0.87 | HTR7 (0.67) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL11255288 | 0.87 | DRD3 (0.86) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL11771624 | 0.85 | DRD3 (0.81) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL25427243 | 0.85 | HTR2A (0.68) | DRD3DRD4DRD2HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL11766370 | 0.84 | DRD3 (0.80) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL11781353 | 0.84 | DRD3 (0.62) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL11768824 | 0.83 | DRD3 (0.61) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL6465788 | 0.82 | HTR2A (0.88) | DRD3DRD4DRD2HTR2AHTR1A | |
| SCHEMBL30831823 | 0.82 | HTR2A (0.72) | DRD3DRD4DRD2HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE28973-E | PARKINSON'S DISEASE | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-09-21 | — | — | US | claimed |
| US-4358456-A | Antipsychotic piperidinomethyl-indole derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1982-11-09 | — | — | US | disclosed |
| US-RE28973-E | PARKINSON'S DISEASE | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-09-21 | — | — | US | disclosed |