Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 17/20 | 0.86 |
| ▸ | DRD4 | P21917 | 16/20 | 0.86 |
| ▸ | DRD2 | P14416 | 16/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | NPC1 | O15118 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | HTR1A | P08908 | 1/20 | 0.82 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.82 |
| ▸ | DRD1 | P21728 | 1/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.82 |
| ▸ | HTR2A | P28223 | 1/20 | 0.82 |
| ▸ | HTR2C | P28335 | 1/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29390168 | 0.90 | DRD3 (1.00) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL14281099 | 0.90 | DRD4 (0.80) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL11253588 | 0.90 | DRD3 (1.00) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL11254792 | 0.87 | DRD3 (0.72) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL11265144 | 0.87 | DRD3 (0.75) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL22928541 | 0.83 | DRD3 (1.00) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL1849016 | 0.78 | LMNA (0.90) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL10463380 | 0.78 | LMNA (0.97) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL11270827 | 0.78 | DRD3 (0.88) | DRD3DRD4DRD2CYP2D6LMNA | |
| SCHEMBL8789790 | 0.77 | LMNA (1.00) | DRD3DRD4DRD2CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4358456-A | Antipsychotic piperidinomethyl-indole derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1982-11-09 | — | — | US | claimed |
| US-4358456-A | Antipsychotic piperidinomethyl-indole derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1982-11-09 | — | — | US | disclosed |