Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250256 | 0.83 | FLT1 (0.53) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL4574528 | 0.81 | FLT1 (0.51) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL107882 | 0.81 | FLT1 (0.51) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL30628195 | 0.81 | FLT1 (0.51) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL109654 | 0.81 | SMN1; SMN2 (0.63) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL824683 | 0.80 | HPGD (0.51) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL14660084 | 0.79 | SMN1; SMN2 (0.61) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL18330324 | 0.79 | FLT1 (0.50) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL2468739 | 0.79 | KDM4E (0.55) | FLT1FLT4KDRSMN1; SMN2TSHR | |
| SCHEMBL9555496 | 0.79 | FLT1 (0.50) | FLT1FLT4KDRSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337341-A | 4a-Aryl-octahydro-1H-2-pyrindines | ELI LILLY AND COMPANY (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0002937-A1 | Novel pyrindines and their preparation, formulations and use | ELI LILLY AND COMPANY (US) | 1979-07-11 | — | — | EP | disclosed |