Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11390896 | 1.00 | ALDH1A1 (0.55) | ALDH1A1NPSR1MAPTCYP1A2TSHR | |
| SCHEMBL11380096 | 0.91 | ALDH1A1 (0.51) | ALDH1A1NPSR1MAPTCYP1A2TSHR | |
| SCHEMBL11256983 | 0.91 | ALDH1A1 (0.51) | ALDH1A1NPSR1MAPTCYP1A2TSHR | |
| SCHEMBL11249228 | 0.85 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11388178 | 0.84 | ALDH1A1 (0.47) | ALDH1A1MAPTCYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL11247958 | 0.84 | ALDH1A1 (0.47) | ALDH1A1MAPTCYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL11381243 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2GAARAB9A | |
| SCHEMBL11381249 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2GAARAB9A | |
| SCHEMBL11246074 | 0.82 | ALDH1A1 (0.36) | ALDH1A1NPSR1MAPTCYP1A2TSHR | |
| SCHEMBL11385545 | 0.82 | KMT2A (0.50) | ALDH1A1NPSR1MAPTCYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009560-A1 | 1,4-Dihydropyridazine-3-carbonyl compounds, process for their preparation, the compounds for use in curing diseases, medicaments containing them and process for the preparation of the medicaments | BAYER AG (DE) | 1980-04-16 | — | — | EP | claimed |
| EP-0009560-B1 | 1,4-DIHYDROPYRIDAZINE-3-CARBONYL COMPOUNDS, PROCESS FOR THEIR PREPARATION, THE COMPOUNDS FOR USE IN CURING DISEASES, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THE PREPARATION OF THE MEDICAMENTS | BAYER AG (DE) | 1982-09-22 | — | — | EP | disclosed |
| US-4280998-A | 1,4-Dihydropyridazine-3-carboxylic acid derivatives, a process for their preparation and their use as antihypertensives | BAYER AKTIENGESELLSCHAFT (DE) | 1981-07-28 | — | — | US | disclosed |