Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPIB | P23284 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11298659 | 0.98 | ALDH1A1 (0.46) | ALDH1A1CYP3A4HPGDHIF1AHSD17B10 | |
| SCHEMBL11378414 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CYP3A4HPGDHIF1AHSD17B10 | |
| SCHEMBL11394086 | 0.83 | HDAC3 (0.41) | ALDH1A1CYP3A4HPGDHIF1AHSD17B10 | |
| SCHEMBL11381126 | 0.82 | HDAC3 (0.38) | ALDH1A1CYP3A4HPGDHIF1AHSD17B10 | |
| SCHEMBL11155942 | 0.75 | PPIB (0.42) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL11248793 | 0.75 | MAPT (0.53) | ALDH1A1PPIBHDAC3HDAC4HDAC1 | |
| SCHEMBL11248037 | 0.74 | HDAC3 (0.43) | PPIBHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL11150119 | 0.73 | MAPT (0.45) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL11152982 | 0.73 | PPIB (0.42) | PPIBHDAC3HDAC4HDAC1HDAC7 | |
| Spizofurone SCHEMBL933718 | 0.73 | KDM4E (0.46) | ALDH1A1CYP3A4PPIBHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | claimed |
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | claimed |
| EP-0003084-A1 | Spirobenzofuranone compounds, processes for their preparation and their use as medicines | Takeda Chemical Industries, Ltd. (JP) | 1979-07-25 | — | — | EP | claimed |
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | disclosed |
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | disclosed |