Spizofurone

Spizofurone

SCHEMBL933718

CC(=O)c1ccc2c(c1)C(=O)C1(CC1)O2

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.46
▸ HDAC3 O15379 5/20 0.44
▸ HDAC4 P56524 5/20 0.44
▸ HDAC1 Q13547 5/20 0.44
▸ HDAC7 Q8WUI4 5/20 0.44
▸ HDAC2 Q92769 5/20 0.44
▸ HDAC10 Q969S8 5/20 0.44
▸ HDAC11 Q96DB2 5/20 0.44
▸ HDAC8 Q9BY41 5/20 0.44
▸ HDAC6 Q9UBN7 5/20 0.44
▸ HDAC9 Q9UKV0 5/20 0.44
▸ HDAC5 Q9UQL6 5/20 0.44
▸ PPIB P23284 1/20 0.42
▸ S100A4 P26447 1/20 0.41
▸ NPC1 O15118 2/20 0.41
▸ RAB9A P51151 2/20 0.41
▸ MAPT P10636 2/20 0.41
▸ HSD17B1 P14061 1/20 0.36
▸ TLK2 Q86UE8 1/20 0.36
▸ AKR1B1 P15121 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Spizofurone SCHEMBL29493300 1.00 KDM4E (0.46) KDM4EHDAC3HDAC4HDAC1HDAC7
SCHEMBL10334515 0.86 HDAC3 (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11386477 0.84 PPIB (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL13182901 0.84 ATM (0.54) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11248254 0.81 CYP1A2 (0.54) KDM4EHDAC3HDAC4HDAC1HDAC7
SCHEMBL13158976 0.81 HDAC3 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18157491 0.79 S100A4 (0.46) KDM4ES100A4NPC1RAB9AMAPT
SCHEMBL11248793 0.77 MAPT (0.53) KDM4EHDAC3HDAC4HDAC1HDAC7
SCHEMBL11379323 0.75 HDAC3 (0.44) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL13481991 0.74 MAPT (0.66) KDM4ENPC1MAPTALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 620 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4690805-A1 METHODS AND DEVICES FOR INTRA BLOCK COPY AND INTRA TEMPLATE MATCHING Beijing Dajia Internet Information Technology Co., Ltd. (CN) 2026-02-11 — — EP claimed
EP-4522159-A1 COMPOSITIONS AND METHODS FOR TREATING EPILEPSY Poviva Corp. (US) 2025-03-19 — — EP claimed
EP-4518846-A1 COMPOSITIONS AND METHODS FOR TREATING EPILEPSY Poviva Corp. (US) 2025-03-12 — — EP claimed
WO-2025042560-A1 METHODS AND DEVICES FOR INTRA BLOCK COPY Beijing Dajia Internet Information Technology Co., Ltd. (CN) 2025-02-27 — — WO claimed
WO-2025024007-A1 COMPOSITIONS AND METHODS FOR TREATING EPILEPSY POVIVA CORP . (US) 2025-01-30 — — WO claimed
WO-2024213784-A1 NUTRIENT MEDIUM FOR BIOLUMINESCENT BACTERIA AND DEVICE FOR THE IMPLEMENTATION THEREOF BRIAND, Germain (FR) 2024-10-17 — — WO claimed
WO-2024211853-A1 METHODS AND DEVICES FOR INTRA BLOCK COPY AND INTRA TEMPLATE MATCHING BEIJING DAJIA INTERNET INFORMATION TECHNOLOGY CO., LTD (CN) 2024-10-10 — — WO claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
US-8779870-B2 Low phase variation CMOS digital attenuator INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2014-07-15 — — US claimed
US-20130088403-A1 Low Phase Variation CMOS Digital Attenuator INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2013-04-11 — — US claimed
WO-2004006902-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OR MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 — — WO claimed
US-20040010035-A1 Gastrointestinal compositions MCNEIL-PPC, INC 2004-01-15 — — US claimed
US-20040010034-A1 Gastrointestinal compositions WARNER-LAMBERT COMPANY 2004-01-15 — — US claimed
US-20040009234-A1 Gastrointestinal compositions WARNER-LAMBERT COMPANY 2004-01-15 — — US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 — — EP claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 — — CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 — — EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 — — WO claimed
EP-0003084-B1 SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES Takeda Chemical Industries, Ltd. (JP) 1982-02-24 — — EP claimed
US-4284644-A Spirobenzofuranone compounds TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1981-08-18 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040010034-A1 Gastrointestinal compositions FABP2, SLC10A2, FABP6 KDM4E 4537/4885HDAC3 1717/4885HDAC4 1996/4885
US-20040009234-A1 Gastrointestinal compositions FABP2, SLC10A2, FABP6 KDM4E 4537/4885HDAC3 1717/4885HDAC4 1996/4885
US-20040010035-A1 Gastrointestinal compositions FABP2, SLC10A2, FABP6 KDM4E 4537/4885HDAC3 1717/4885HDAC4 1996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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