Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | PDE8A | O60658 | 10/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10061961 | 0.85 | PDE8A (0.50) | CDK1PDE8ACCNB1CCNE1CDK2 | |
| SCHEMBL10638325 | 0.84 | LMNA (0.59) | CDK1PDE8ACCNB1CCNE1CDK2 | |
| SCHEMBL2293264 | 0.80 | ADORA2A (0.68) | ADORA2AADORA1ALDH1A1CYP3A4 | |
| SCHEMBL3441119 | 0.79 | CDK1 (0.58) | CDK1PDE8ACCNB1CCNE1CDK2 | |
| SCHEMBL11240739 | 0.77 | PNP (0.60) | CDK1PDE8APDE4DLMNABLM | |
| SCHEMBL3440998 | 0.77 | CDK1 (0.71) | CDK1PDE8ACCNB1CCNE1CDK2 | |
| SCHEMBL3441000 | 0.77 | CDK1 (0.55) | CDK1PDE8ACCNB1CCNE1CDK2 | |
| SCHEMBL23619320 | 0.75 | CDK1 (0.60) | CDK1PDE8ACCNB1CCNE1CDK2 | |
| SCHEMBL24835574 | 0.75 | CDK1 (0.59) | CDK1PDE8ACCNB1CCNE1CDK2 | |
| SCHEMBL3441081 | 0.75 | CDK1 (0.64) | CDK1PDE8ACCNB1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360522-A | VIRICIDES | BURROUGHS WELLCOME CO. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4323573-A | VIRICIDES | BURROUGHS WELLCOME CO. (US) | 1982-04-06 | — | — | US | disclosed |
| US-4199574-A | Methods and compositions for treating viral infections and guanine acyclic nucleosides | BURROUGHS WELLCOME CO. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4146715-A | ANTIVIRAL AGENTS | BURROUGHS WELLCOME CO. (US) | 1979-03-27 | — | — | US | disclosed |