Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11877229 | 0.91 | TSHR (0.31) | TSHR | |
| SCHEMBL11881567 | 0.88 | — | — | |
| Bicarbonate SCHEMBL5672941 | 0.82 | MEN1 (0.40) | TSHRMEN1KMT2ACTSLCTSB | |
| Bicarbonate SCHEMBL2124476 | 0.82 | MEN1 (0.40) | TSHRMEN1KMT2ACTSLCTSB | |
| SCHEMBL20484020 | 0.80 | CYP2C19 (0.34) | TSHRCYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL6278444 | 0.80 | CYP2C19 (0.34) | TSHRCYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL14655770 | 0.80 | KDM4E (0.30) | TSHRCYP2C19MEN1KMT2AKDM4E | |
| SCHEMBL14655833 | 0.77 | MEN1 (0.31) | TSHRMEN1KMT2A | |
| SCHEMBL20484018 | 0.77 | CYP2C19 (0.31) | TSHRCYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL14990797 | 0.77 | CYP2C19 (0.31) | TSHRCYP2C19MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4345056-A | Process for suspension polymerization of vinyl chloride employing mixed protective colloids | WACKER-CHEMIE GMBH (DE) | 1982-08-17 | — | — | US | disclosed |