Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281996 | 0.89 | HRH1 (0.62) | HTR2ASLC6A3CHRM2CHRM1HRH1 | |
| Hydrochloric Acid SCHEMBL7274257 | 0.87 | HRH1 (0.60) | HTR2ASLC6A3CHRM2CHRM1HRH1 | |
| SCHEMBL11249446 | 0.78 | HTR2A (0.60) | HTR2ASLC6A3CHRM2CHRM1HRH1 | |
| SCHEMBL1979887 | 0.76 | SLC6A4 (0.65) | HTR2ASLC6A3CHRM2CHRM1HRH1 | |
| SCHEMBL11241825 | 0.74 | SMN1; SMN2 (0.45) | CNR1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL17802362 | 0.72 | HTR2A (0.63) | HTR2ASLC6A3CHRM2CHRM1HRH1 | |
| SCHEMBL16260323 | 0.72 | HTR2A (0.56) | HTR2ASLC6A3CHRM2CHRM1SLC6A4 | |
| SCHEMBL17685575 | 0.72 | TAAR1 (0.48) | HTR2ASLC6A3CHRM2CHRM1HRH1 | |
| SCHEMBL1291652 | 0.72 | LMNA (0.52) | HTR2ASLC6A3CHRM2CHRM1HRH1 | |
| SCHEMBL5468813 | 0.70 | LMNA (0.61) | HTR2ASLC6A3CHRM2CHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000322-B1 | COMPOUNDS HAVING AN ANTI-DEPRESSIVE OR TRANQUILIZING ACTIVITY, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | Astra Läkemedel Aktiebolag (SE) | 1982-05-05 | — | — | EP | disclosed |
| EP-0028682-A2 | Intermediates useful at the preparation of compounds having anti-depressive or tranquilizing activity | Astra Läkemedel Aktiebolag (SE) | 1981-05-20 | — | — | EP | disclosed |