Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.62 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.62 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.62 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.62 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7274257 | 0.98 | HRH1 (0.60) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| SCHEMBL11258499 | 0.89 | HTR2A (0.52) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| SCHEMBL17685575 | 0.81 | TAAR1 (0.48) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| SCHEMBL1291652 | 0.81 | LMNA (0.52) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| SCHEMBL14415598 | 0.79 | CACNA1F (0.42) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| Terodiline SCHEMBL9008621 | 0.77 | HRH1 (1.00) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| Terodiline SCHEMBL78908 | 0.77 | HRH1 (1.00) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| SCHEMBL9493121 | 0.75 | HRH1 (0.54) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| Terodiline SCHEMBL121864 | 0.75 | HRH1 (0.96) | HRH1ADRA1ACHRM2SLC6A3KCNH2 | |
| SCHEMBL15130931 | 0.75 | ADRA1A (0.55) | HRH1ADRA1ACHRM2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4968832-A | INTERMEDIATES FOR CORONARY DILATORS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1990-11-06 | — | — | US | disclosed |
| US-4772621-A | Antihypertensive diphenylpropyl aminopropyl ester of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1988-09-20 | — | — | US | disclosed |
| US-4705797-A | HYPOTENSIVE AGENTS, VASODILATORS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1987-11-10 | — | — | US | disclosed |
| EP-0153016-A2 | Asymmetrical diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1985-08-28 | — | — | EP | disclosed |
| US-3946063-A | 2,3,4,5,6-PENTAFLUOROBENZYL CHLOROFORMATE | PIERCE CHEMICAL COMPANY (US) | 1976-03-23 | — | — | US | disclosed |