Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.50 |
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257449 | 0.92 | PLA2G2A (0.52) | PLA2G2APPARGPPARAMEN1KMT2A | |
| SCHEMBL11389302 | 0.91 | PPARG (0.53) | PLA2G2APPARGPPARAMEN1KMT2A | |
| SCHEMBL11257489 | 0.90 | PLA2G2A (0.47) | PLA2G2APPARGPPARAMEN1KMT2A | |
| SCHEMBL11252774 | 0.83 | PLA2G2A (0.49) | PLA2G2APPARGPPARAMEN1KMT2A | |
| SCHEMBL11263543 | 0.83 | KDM4E (0.49) | PLA2G2APPARGPPARAMEN1KMT2A | |
| SCHEMBL11258391 | 0.82 | PPARA (0.53) | PLA2G2APPARGPPARAMEN1KMT2A | |
| SCHEMBL11258878 | 0.81 | PLA2G2A (0.47) | PLA2G2AMEN1KMT2APOLBKDM4E | |
| SCHEMBL11261340 | 0.79 | PPARG (0.53) | PLA2G2APPARGPPARAMEN1KMT2A | |
| SCHEMBL11255132 | 0.79 | GRIK2 (0.58) | PPARGPPARAMEN1KMT2APOLB | |
| SCHEMBL11266787 | 0.78 | PPARG (0.51) | PLA2G2APPARGPPARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |