Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.53 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.46 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262300 | 0.89 | PPARG (0.49) | PPARGPPARAPPARDPLA2G4APLA2G2A | |
| SCHEMBL11257449 | 0.87 | PLA2G2A (0.52) | PPARGPPARAPPARDPLA2G2AMEN1 | |
| SCHEMBL11497969 | 0.80 | PTPN7 (0.50) | PPARGPPARAPPARDPTPN7DUSP3 | |
| SCHEMBL11258718 | 0.79 | PLA2G2A (0.50) | PPARGPPARAPPARDPLA2G2AMEN1 | |
| SCHEMBL11389302 | 0.79 | PPARG (0.53) | PPARGPPARAPPARDPLA2G2AMEN1 | |
| SCHEMBL11252774 | 0.79 | PLA2G2A (0.49) | PPARGPPARAPLA2G2AMEN1KMT2A | |
| SCHEMBL11265231 | 0.76 | PTPN7 (0.46) | PPARGPPARAPPARDPTPN7DUSP3 | |
| SCHEMBL11252321 | 0.76 | SPR (0.53) | PPARGPLA2G4APLA2G2AMEN1KMT2A | |
| SCHEMBL11266787 | 0.75 | PPARG (0.51) | PPARGPPARAPPARDPLA2G2AMEN1 | |
| SCHEMBL11257941 | 0.75 | LMNA (0.47) | PPARGPPARAPPARDPTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |