Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11258416 | 0.88 | POLB (0.47) | GAALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11251910 | 0.86 | ALOX5 (0.43) | GAALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11265814 | 0.86 | SMN1; SMN2 (0.51) | GAALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11263114 | 0.85 | GAA (0.46) | HTR6GAALMNAHPGDSMN1; SMN2 | |
| SCHEMBL11253942 | 0.82 | HPGD (0.51) | GAALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11263207 | 0.82 | HTR6 (0.49) | HTR6GAALMNAHPGDSMN1; SMN2 | |
| SCHEMBL11257022 | 0.82 | MAPK14 (0.43) | GAALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11263982 | 0.79 | CHEK1 (0.54) | GAALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11255963 | 0.79 | HPGD (0.45) | GAALMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL11255454 | 0.78 | ESR1 (0.52) | GAAHPGDSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |