Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254571 | 0.94 | CACNA1B (0.47) | SLC6A3ADORA3POLBCACNA1FCACNA1D | |
| SCHEMBL11256475 | 0.94 | SLC6A3 (0.47) | SLC6A3POLBCACNA1BLMNAMEN1 | |
| SCHEMBL11266291 | 0.91 | ADORA3 (0.53) | ADORA3POLBCACNA1FCACNA1DCACNA1S | |
| SCHEMBL11337775 | 0.84 | NPSR1 (0.38) | SLC6A3POLBCACNA1BLMNAMEN1 | |
| SCHEMBL11270365 | 0.81 | KDM4E (0.50) | SLC6A3ADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL11256300 | 0.79 | KDM4E (0.48) | CACNA1BMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11257667 | 0.79 | ADORA3 (0.57) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL11262343 | 0.79 | CACNA1B (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B | |
| SCHEMBL11332331 | 0.78 | SLC6A3 (0.38) | SLC6A3CACNA1BLMNAMEN1KMT2A | |
| SCHEMBL11343075 | 0.78 | CACNA1B (0.41) | CACNA1BLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360520-A | 1,4-Dihydropyridazine compounds, and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |
| US-4348395-A | 1,4-Dihydropyridazine compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | disclosed |