Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.36 |
| ▸ | CDK8 | P49336 | 3/20 | 0.36 |
| ▸ | FPR1 | P21462 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.30 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.30 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261645 | 0.80 | FPR1 (0.45) | FPR1FPR2ALDH1A1 | |
| SCHEMBL11258355 | 0.69 | FPR1 (0.43) | FPR1FPR2ALDH1A1TDP1 | |
| SCHEMBL11239728 | 0.68 | PDE4A (0.38) | CCNCCDK8CACNA1B | |
| SCHEMBL11250155 | 0.68 | FPR1 (0.42) | FPR1FPR2ALDH1A1HPGD | |
| SCHEMBL11258586 | 0.66 | FPR1 (0.45) | FPR1FPR2ALDH1A1 | |
| SCHEMBL11228219 | 0.63 | KCNH2 (0.46) | CCNCCDK8 | |
| SCHEMBL19441232 | 0.62 | CYP2C19 (0.49) | CCNCCDK8TP53 | |
| SCHEMBL19601134 | 0.62 | CCNC (0.54) | CCNCCDK8ALDH1A1HPGD | |
| SCHEMBL11325503 | 0.61 | CCNC (0.38) | CCNCCDK8 | |
| SCHEMBL12811202 | 0.61 | CCNC (0.45) | CCNCCDK8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |