Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11239728 | 0.72 | PDE4A (0.38) | SMN1; SMN2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL11325503 | 0.72 | CCNC (0.38) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7263634 | 0.71 | KCNH2 (0.73) | KCNH2SMN1; SMN2LMNAMAPTNPY1R | |
| SCHEMBL20703451 | 0.71 | PDE3B (0.69) | KCNH2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL11255964 | 0.70 | CCNC (0.35) | CCNCCDK8 | |
| SCHEMBL11247281 | 0.69 | SMN1; SMN2 (0.67) | KCNH2SMN1; SMN2LMNAPDE3BPDE3A | |
| SCHEMBL20702752 | 0.69 | PDE3B (0.53) | KCNH2SMN1; SMN2LMNAPDE3BPDE3A | |
| SCHEMBL7438685 | 0.69 | PDE3B (0.60) | KCNH2SMN1; SMN2LMNAPDE3BPDE3A | |
| SCHEMBL9631036 | 0.69 | SMN1; SMN2 (0.49) | KCNH2SMN1; SMN2LMNAMAPTNPY1R | |
| SCHEMBL20702740 | 0.68 | PDE3B (0.69) | KCNH2PDE3BPDE3APDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |