Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.58 |
| ▸ | HTR2A | P28223 | 11/20 | 0.58 |
| ▸ | HTR1A | P08908 | 10/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262256 | 0.91 | DRD2 (0.62) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL11263914 | 0.91 | DRD2 (0.61) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL11275359 | 0.91 | DRD2 (0.54) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL11269812 | 0.88 | DRD2 (0.70) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL11262489 | 0.88 | DRD2 (0.56) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL11271057 | 0.88 | DRD2 (0.52) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL11279992 | 0.88 | DRD2 (0.56) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL30767220 | 0.81 | HTR1A (0.80) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL269389 | 0.81 | DRD2 (0.62) | DRD2HTR2AHTR1ASIGMAR1KCNH2 | |
| SCHEMBL30764775 | 0.76 | HTR1A (0.82) | DRD2HTR2AHTR1ASIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062873-A1 | 1-Substituted-4-phenyl-polyhydro-pyridines and -pyrrolidines, processes for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1982-10-20 | — | — | EP | claimed |
| US-4340597-A | 1-Substituted-4-aryl-1,2,5,6-tetrahydro and hexahydropyridines | SCHERING CORPORATION (US) | 1982-07-20 | — | — | US | claimed |
| EP-0062873-A1 | 1-Substituted-4-phenyl-polyhydro-pyridines and -pyrrolidines, processes for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1982-10-20 | — | — | EP | disclosed |