Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | CCR2 | P41597 | 15/20 | 0.61 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266983 | 0.92 | CCR2 (0.53) | APEX1LMNAGAAMAPTHTT | |
| SCHEMBL10487872 | 0.89 | CCR2 (0.60) | APEX1LMNAMAPTCCR2 | |
| SCHEMBL10143727 | 0.89 | MAPT (0.65) | LMNAGAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL10487979 | 0.87 | CCR2 (0.58) | APEX1LMNAGAAMAPTHTT | |
| SCHEMBL9050777 | 0.87 | CCR2 (0.58) | LMNAGAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL11257423 | 0.86 | APEX1 (0.60) | APEX1LMNAGAAMAPTHTT | |
| SCHEMBL11263079 | 0.86 | APEX1 (0.70) | APEX1LMNAHTTSMN1; SMN2CCR2 | |
| SCHEMBL2762171 | 0.85 | APEX1 (0.79) | APEX1LMNAGAASMN1; SMN2CCR2 | |
| SCHEMBL11262526 | 0.83 | LMNA (0.73) | LMNAGAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL11264725 | 0.82 | APEX1 (0.64) | APEX1SMN1; SMN2CCR2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0019440-A1 | Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them | PFIZER INC. (US) | 1980-11-26 | — | — | EP | claimed |
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| EP-0019440-A1 | Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them | PFIZER INC. (US) | 1980-11-26 | — | — | EP | disclosed |
| US-4209527-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |