Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11249938 | 0.90 | TDP1 (0.45) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11261355 | 0.86 | TDP1 (0.50) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11250215 | 0.83 | TDP1 (0.46) | TDP1CYP1A2KDM4EMAPTPPARG | |
| Formamide SCHEMBL11440222 | 0.81 | TDP1 (0.44) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11249116 | 0.76 | TDP1 (0.47) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11263624 | 0.75 | TDP1 (0.44) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11248912 | 0.75 | TDP1 (0.50) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11311256 | 0.75 | TDP1 (0.53) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11251937 | 0.75 | TDP1 (0.46) | TDP1CYP1A2KDM4EMAPTPPARG | |
| SCHEMBL11261670 | 0.74 | ALDH1A1 (0.45) | TDP1CYP1A2KDM4EMAPTPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |